Data for: Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques

Recording and modulating neural activity in vivo enables investigations of
the neurophysiology underlying behavior and disease, but there is a dearth
of translational tools for simultaneous recording and localized
receptor-specific modulation. We addressed this limitation by translating
multifunctional fiber neurotechnology previously only available for rodent
studies to enable cortical and subcortical neural recording and modulation
in macaques. In the premotor cortex and putamen, we recorded single-neuron
activity and local field potential oscillations during intracranial GABA
infusions while a macaque performed a working memory task. We also
recorded neuronal activity during saline, artificial cerebrospinal fluid,
and no infusion control experiments. We characterized the dynamic effects
of local infusions with multiple time series analysis techniques,
including spectrotemporal analysis and state-space modeling. This dataset
and accompanying software toolbox provide detailed insight into the
electrophysiological effect of neurotransmitter receptor modulation in
both cortical and subcortical structures in an awake macaque.