Structurally Diverse Nitrogen-Rich Scaffolds via Continuous Photo-Click Reactions

Continuous flow technology was exploited for the effective
generation
of nitrile imines via photolysis of substituted aryl tetrazoles. The
resulting photo-click process rapidly affords advanced nitrogen-rich
scaffolds upon the subsequent trapping of the reactive dipole with
alkenes, alkynes, and benzylic amines. Crucially, this approach uncovers
the differential reactivity for ether vs amine tethers, thus providing
facile and scalable access to underexplored medicinally relevant heterocyclic
entities.