Antibiotic aerosolization modulates the taxonomic composition of pulmonary bacterial communities associated with tumor growth.

Lung tissues harbor a resident microbiota, which plays a role in regulating pulmonary immune tolerance. Different studies show that lung microbiota is modified by the presence of a growing tumor. We previously reported that lung microbiota manipulation by antibiotics/probiotics aerosolization reverts immunosuppression and prevents melanoma and breast carcinoma lung metastases. Here, we evaluate the changes in pulmonary microbiota composition associated with the growth of the LLC1 lung carcinoma, and how the antibiotic treatment modifies the bacterial species associated with lung tumor.