Cooperative JAK-STAT/MAP-kinase/MYC deregulation in Plasmablastic Lymphoma

Plasmablastic lymphoma is an aggressive B-cell lymphoma with an immunoblastic/large cell morphology anda plasmacytic differentiation. The differential diagnosis with Burkitt lymphoma, plasma cell myeloma and some variants of diffuse large B-cell lymphoma may be challenging due to the overlapping morphological, genetic and immunophenotypic features. Furthermore, the profile of chromosomal alterations is not well known. The aim of this study was to perform a complete genetic characterization of PBL. Thirty-four cases were analyzed byFISH, copy number array and targeted next-generation sequencing of 94 B-cell lymphoma related genes.