Ferroptosis-related long non-coding RNA signature predicts the prognosis of lung adenocarcinoma

Studies indicate the occurrence and development of lung adenocarcinoma (LUAD) is regulated by ferroptosis and long non-coding RNA (lncRNA). While the role of ferroptosis-related lncRNA signature on the prognosis of LUAD is unclear. This study aimed to identify ferroptosis-related lncRNA signature for predicting the prognosis of LUAD. RNA expression profile and clinical data of LUAD patients were downloaded from public databases. The cox regression model was used to construct a multi-lncRNA signature. A total of 13 differentially expressed ferroptosis-related lncRNAs were significantly associated with the prognosis of LUAD. Kaplan-Meier survival curve analysis showed that patients in the high-risk group had a worse prognosis than those in the low-risk group. In addition, the area under the time-dependent receiver operating characteristic curve of 13 lncRNAs signature for predicting LUAD was 0.728. Gene set enrichment analysis suggested immune and tumor-related pathways were mainly concentrated in the low-risk group. Furthermore, immune functions such as T cell-cosuppression, T cell-costimulation, type I interferon response, and type II interferon response between the low-risk group and the high-risk group were significantly different. In conclusion, we identified a new ferroptosis-related lncRNA signature for predicting the prognosis of LUAD. Targeted ferroptosis may be a therapeutic option for LUAD.