Transcriptomic analysis of natural killer (NK) cells after co-culture with RPMI 8226 multiple myleoma cell line in the presence or absence of peripheral blood lymphocytes

Isatuximab is an IgG1 antibody that recognizes CD38 molecule on the surface of MM plasma cells and induces, among others, NK cell-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). In this study we sough to unveil the effect of anti-CD38 antibody on NK cells We used microarrays to detail the global programme of gene expression underlying the differences among NK cells co-cultured with RPMI 8226 cells in the presence or absence of anti-CD38 antibody RPMI 8226 MM cell line was co-cultured with or without anti-CD38 antibody in the presence or absence of human PBLs and the effect of the antibody over FACS sorted MM cell line and NK cells was analyzed by gene expression profile