ursodeoxycholic acid on immune-related gene expression in large yellow croaker

RNA sequencing analysis revealed that UDCA supplementation upregulated genes associated with nonspecific immune functions in liver and intestinal tissues, notably those related to complement pathways and antioxidant. Furthermore, weighted gene coexpression network analysis (WGCNA) identified clusters of genes linked to immunity, including those involved in cytokine production and antiviral responses.