RNAseq of ipsilateral mouse brain homogenates 1 day following collagenase-induced ICH vs naive controls

Intracerebral haemorrhage (ICH) is a major area of unmet clinical need. Inflammation is part of a secondary injury phase linked to both brain damage and repair. Here, we looked to identify the major molecular pathways promoting innate immune activation and recruitment in the first day of injury. To do this, we induced ICH in six month old C57BL/6 male mice (n=4) and isolated RNA from the right (ipsilateral) hemisphere 24 hours later. We used RNA isolated from right hemispheres of six month old naive male C57BL/6 mice (n=3) as controls.