Acute effects of esculentin-2CHa and its analogues on glucose tolerance and insulin release in high fat fed mice.

Plasma glucose and insulin were measured prior to and after intraperitoneal administration of high fat fed mice with glucose (18 mmol/kg) alone (control) or in combination with peptide (75 nmol/kg body weight). Integrated responses to are presented as area under the curve values (AUC) for data collected at 0, 15, 30 and 60 min after peptide administration. Values are mean ± SEM with n = 8.*P **P ΔP ΔΔPΔΔΔPAcute effects of esculentin-2CHa and its analogues on glucose tolerance and insulin release in high fat fed mice.