Gene expression profiles in paediatric ETV6-RUNX1 leukemia

ETV6-RUNX1 (E::R) subgroup is the second most frequent form of B cell acute lymphoblastic leukemia (B-ALL) in childhood. This subgroup of ALL generally presents with low-risk features and responds well to chemotherapy with ensuing favorable prognosis. Some patients, however, have a slow response to induction treatment and carry increased risk for relapse. The aim of this study is to identify differences in gene expression between E::R cases stratified by MRD (NOPHO ALL2008 protocol), and to identify potential mediators of poor therapy response.EGA study EGAS00001007097