Recent reports suggest that induced neurons (iNs), but not induced pluripotent stem cell (iPSC)-derived neurons largely preserve age-associated traits. Here we report on the extent of preserved epigen
16p13.11 copy number variants (CNVs) have been associated with autism, schizophrenia, psychosis, intellectual disability, and epilepsy. The majority of 16p13.11 deletions or duplications occur within
Harnessing the self-organizing abilities of human embryonic stem cells to mimic normal and aberrant development is a pressing challenge. Generation of highly reproducible and standardized models would
