Prostaglandin D2 Signaling in Tendon Healing

We report RNA sequencing data from the plantaris tendons of 3-month old Sprague Dawley rats that were treated with vehicle or GSK2894631A to inhibit the HPGDS enzyme. Rats underwent a bilateral plantaris tendon tear followed by immediate repair, and samples were obtained either 7 or 21 days after surgical intervention. Differential expression of mRNAs were evaluated between the plantaris tendons of control rats or rats that were subjected to a plantaris tendon tear and repair and received 0mg/kg, 2mg/kg, or 6mg/kg of GSK2894631A twice daily for 7 or 21 days.