Rab4a:GTP Activates Kif3

Insulin signals via PKC-lambda to cause Rab4 to load GTP and associate with Kif3, which then has higher affinity for microtubules (Imamura et al. 2003). Motor activity of Kif3 along microtubules is believed to transport vesicles containing Glut4 (Slc2a4) across the cytosol to the cortical actin network.

胰岛素信号通过PKC-lambda途径诱导Rab4负载GTP，并与Kif3结合，随后Kif3对微管的亲和力增强（Imamura等，2003年）。据信Kif3沿微管运动的活动能够将包含Glut4（Slc2a4）的囊泡沿细胞质运输至皮质肌动蛋白网络。