The role of TERT in hepatocarcinogenesis

NIAID Data Ecosystem2026-05-02 收录

肝细胞癌病因

TERT基因功能

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https://www.ncbi.nlm.nih.gov/sra/DRP013524 数据链接链接失效反馈

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In the current study, we aimed to elucidate the significance of aberrant TERT expression in hepatocytes during inflammation-associated hepatocarcinogenesis by using Alb-Cre;TertTg mice which overexpress Tert specifically in hepatocytes.

创建时间：

2025-06-29

Impact of high fat diet and hepatocyte nuclear factor four alpha loss on hepatic gene expression in mice.. Impact of high fat diet and hepatocyte nuclear factor four alpha loss on hepatic gene expression in mice.

基因表达调控

肝细胞癌病因

The transcription factor hepatocyte nuclear factor four alpha (Hnf4a) has various isoforms, one of which (P1-Hnf4a) is expressed in adult liver, where it functions as a tumor suppressor by providing c

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A maternal high-fat diet induces fetal origins of NASH-HCC in mice

非酒精性脂肪性肝病机制

肝细胞癌病因

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Sublethal necroptosis signaling promotes inflammation and liver cancer. Sublethal necroptosis signaling promotes inflammation and liver cancer

肝细胞癌病因

坏死性凋亡信号通路

We developed a genetic mouse model of chronic necroptosis activation in hepatocytes (in the presence of basal NF-kB activity) that lead to hepatocellular carcinoma. Blocking Necroptosis (RIP3) or NF-k

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Midnolin Regulates Liver Cancer Cell Growth In Vitro and In Vivo. Midnolin Regulates Liver Cancer Cell Growth In Vitro and In Vivo

肝细胞癌病因

基因功能研究

Hepatocellular carcinoma (HCC) ranks worldwide as one of the most lethal cancers. In spite of the vast existing knowledge about HCC, the pathogenesis of HCC is not completely understood. Discovery of

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Upregulation of the Wnt Co-Receptor LRP6 Promotes Hepatocarcinogenesis and Enhances Cell Invasion

肝细胞癌病因

Wnt/β-catenin信号通路

BackgroundActivation of the Wnt/β-catenin signaling pathway plays a crucial role in hepatocellular carcinoma (HCC). Low-density lipoprotein (LDL) receptor-related protein-6 (LRP6) is one of the co-rec

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The role of TERT in hepatocarcinogenesis

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