Fold-change of tissue fatty acid amide levels following treatment with URB597 or WIN 55,212-2 relative to vehicle treatment.

Values are fold-changes compared to vehicle treatment levels in spinal cord injured (SCI) and non-injured (N.I.) rats. On the seventh day of treatment, tissues were collected 4 hours post-administration with either vehicle, URB597 (URB, 3 mg/kg, i.p.) or WIN 55,212-2 (WIN, 3 mg/kg, s.c.) from SCI rats. Non-injured rats were treated once and tissues collected four hours post-treatment. In one set of non-injured rats (n = 5), tissues were collected two hours (2 h) post-treatment with URB597.
“Epicenter” refers to thoracic spinal cord tissue either from the site of injury from SCI rats or comparable spinal cord tissue from non-injured rats.
n.s., not significant.
*p<0.05, **p<0.01, ***p<0.001 vs. vehicle-treated (Student's t-test).