Study of the morphological effects of insulin treatment in mouse model of Alzheimer's disease

The pathophysiology of Alzheimer's disease (AD) remains unclear. However, an increasing number of studies suggest that cerebral insulin resistance may play an important role in the development and progression of AD, and that insulin treatment can improve cognitive performance, suggesting a neuroprotective effect of this hormone. Using X-ray phase contrast tomography, this proposal aims to investigate the morphological effects of an insulin treatment - a candidate therapeutic intervention for dementia - on AD mice. We will investigate changes in the neurovascular network, Aβ plaques and cellular microenvironment of the brain in AD mice treated with insulin. In addition, given the research highlighting the important role of the gut in insulin resistance and AD development, we plan to simultaneously investigate possible structural changes in the gut.