Transcriptional analysis of hepatoxicity induced by hexafluoropropylene oxide trimer acid (HFPO-TA)

Transcriptome sequencing identified a set of hepatic relative biological processes that responding to HFPO-TA exposure, PPAR was the most significantly enriched pathway in KEGG analysis, and genes including ALB, FABP1, CXCL12, AHSG, FGA, FGB, etc. with high degrees in PPI network, were characterized as hub genes. Overall design: Total RNA was isolated from the induced hepatocytes exposed HFPO-TA or 0.1% DMSO, each containing 3 replicates.