Alterations of splicing and gene expression in DMSO or 4OHT treated-IMR90 ER:HRAS G12V cells upon knockdown of SF3B1 and RBM39

The goal of this study was to analyse changes of splicing and gene expression induced in IMR90 Control and IMR90 RAS (HRASG12V) cells upon knockdown of splicing factors SF3B1 and RBM39 Overall design: Comparative analysis of splicing and gene expression changes in DMSO-treated IMR90 ER:RAS (control) and 4OHT-induced IMR90 ER:RAS cells following the knockdown of SF3B1 and RBM39 by siRNA (siSF3B1 and siRBM39) compared to non-targeting siRNA (siNT).