Sequencing of adenovirus from clinical samples. Clinical adenovirus epidemiology

Adenoviruses are significant pathogens for the immune supressed. Adenoviraemia post-bone marrow is associated with increased treatment costs, longer hospital stays, and increased morbidity and mortality. Whole-genome sequencing of adenovirus provides a wealth of clinically relevant information on genome variation, including phylogeography, resolution of locally circulating subtypes and improved molecular epidemiology, the capacity to identify new recombinant subtypes, and mutation data in response to antiviral drug selection pressure. https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiy323/5032622