NPM1_ex_vivo_CRISPR. NPM1_ex_vivo_CRISPR
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下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJEB11979
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资源简介：
Acute myeloid leukaemia (AML) continues to have a very high mortality and its treatment has not changed for more than 20 years. Here, we propose to apply genomic-wide screens to directly identify therapeutic vulnerabilities of AML using AML cells lines with pre-defined somatic mutations. Our studies will be based on genome-wide CRISPR/CAs9 gRNA screens and will be used to identify drivers of drug resistance to standard chemotherapies.
创建时间：
2016-03-23
