Effects of Korean red ginseng against the influence of bisphenol A on ovariectomized mouse liver and uterus

Bisphenol A (BPA), known as an endocrine disruptor, is widely used in the world. BPA is reported to cause inflammation-related diseases. Although efforts to identify the effects of BPA are ongoing, the impact of BPA on postmenopausal women is not well known. Korean red ginseng (KRG) has been used safely in human for a long time for the treatment of diverse diseases. KRG has been reported of its mitigating effect on menopausal symptoms and suppress adipose inflammation. Here, we investigate the protective effect of orally administered KRG on the impacts of BPA in the liver and uterus of menopausal mouse model. Overall design: Six-weeks-old female CD-1 mice were ovariectomized and had 1 week of purification period. Gene expression of liver was measured after exposed for 7 days to bisphenol A at dose 200 mg/kg/day with or without Korean red ginseng at dose 1.2g/kg/day via oral administration.