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Cardiac organoids for Hypertophic cardiomyopathy

NIAID Data Ecosystem2026-05-02 收录

类器官疾病建模

肥厚型心肌病分子表型

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE263591 数据链接链接失效反馈

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资源简介：

Outcome Spatial molecular imaging to evaluate the difference between organoids generated from WT and D389V mutant carrier. contains data for both Mutant and NC organoids

应用场景：

创建时间：

2025-01-29

类器官疾病建模

心肌梗死模型

While human organoid systems have provided a powerful platform in modeling diseases caused by genetic disorders, non-genetic factors, such as lifestyle and environment, are the largest attributable fa

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An organoid model to assay the role of CFTR in the human epididymis epithelium

类器官疾病建模

CFTR药物研究

Organoid cultures derived from primary human tissues facilitate the study of disease processes and the development of new therapeutics. We used human epididymis epithelial cell (HEE) organoids and pol

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Genome-wide expression analysis of EPCAM+ epithelial cells from 3-dimensional lung organoids harboring Hermansky-Pudlak Syndrome-associated mutations

类器官疾病建模

基因表达谱分析

Introduction of Hermansky-Pudlak Syndrome-associated mutations with CRISPR/Cas9 genome editing, allows for disease modeling in 3D cultures of hPSC-derived lung organoids. Overall design: Wild-type hum

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Exome-seq of Glioblastoma Tumors and GBOs

脑肿瘤基因组学

类器官疾病建模

Analysis of glioblastoma tissue and corresponding glioblastoma organoids by Exome sequencing. Overall design: Exome sequencing of glioblastoma tumor samples and corresponding glioblastoma organoids

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Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome [rRNA-depleted organoids]

类器官疾病建模

发育代谢调控

Mutations in the mitochondrial complex IV assembly factor SURF1 represent a major cause of Leigh syndrome (LS), a fatal neurological disorder. SURF1-deficient animals failed to recapitulate the neuron

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Cardiac organoids for Hypertophic cardiomyopathy

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