Quantitative proteomic analysis reveals effects of EGFR on invasion-promoting proteins secreted by glioblastoma cells.

Data from PeptideAtlas, [[http://www.peptideatlas.org/PASS/PASS00455 PASS00455]]. Experiment: PTEN+EGFR_1, file: folder summary. Published as part of Mol Cell Proteomics. 2014 Jul 5 . From the Abstract: {{i}} ... To better understand how EGFR contributes to tumor aggressiveness, we investigated the effect of EGFR on the secreted levels of 65 rationally selected proteins involved in invasion. We employed selected reaction monitoring (SRM) targeted mass spectrometry using stable isotope labeled internal peptide standards to quantity proteins in the secretome from five GBM (U87) isogenic cell lines in which EGFR, EGFRvIII and/or PTEN were expressed. {{/i}}