Combination treatment of PTUPB with enzalutamide in C4-2B MDVR cells

To explore the gene regulatory mechanisms underlying PTUPB treatment in drug-resistant prostate cancer cells. We performed RNA sequencing analyses using PTUPB-treated C4-2B MDVR cells with or without enzalutamide treatment to identify the gene programs affected by the treatments. Overall design: Comparative gene expression profiling analysis of RNA-seq data for C4-2B MDVR cells and its treatments (20 µM enzalutamide, PTUPB 10 µM to PTUPB 20 µM and their combination).