Assess the effects of antipsychotic use on gene expression changes in dementia
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE149611
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In order to elucidate mechanisms underlying adverse effects of antipsychotic use in dementia we generated gene expression signatures for three antipsychotics representing a range of mechanisms of action relevant to the current landscape of drug development and clinical use in dementia: amisulpride (primarily a D2/D3 antagonist), risperidone (primarily a 5HT2A/D2 antagonist) and volinanserin (highly selective 5HT2A inverse agonist). We reported that the antipsychotic signatures would be score positively with conditions and diseases related to known side effects of their use in dementia such as cardiovascular and infectious diseases. Examining the effects of 3 antipsychotics on the gene expression changes using SH-SY5Y neuroblastoma cell line
创建时间：
2020-09-01
