<i>Mlh1</i> is an enhancer of nuclear mutant huntingtin immunostaining in B6.<i>Hdh<sup>Q111/+</sup></i> mice.
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(A) Representative EM48 immunostained histological sections from striata of 22-week-old B6.HdhQ111/+ mice on different Mlh1 genetic backgrounds. Mlh1+/+, CAG113; Mlh1+/−, CAG108; Mlh1−/−, CAG110. (B) Quantification of diffuse nuclear EM48 staining demonstrates a statistically significant reduction in the absence of Mlh1. Mlh1+/+, CAG115.3±4.9SD, n = 6; Mlh1+/−, CAG112.0±2.1SD, n = 6; Mlh1−/−, CAG109.2±2.9SD, n = 5. Bar graphs represent mean ±SD. **, p<0.01.
创建时间：
2013-10-31
