Queensland Twin Adolescent Brain (QTAB)
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The Queensland Twin Adolescent Brain (QTAB) Project We describe the Queensland Twin Adolescent Brain (QTAB) dataset and provide a detailed methodology and technical validation to facilitate data usage. The QTAB dataset comprises multimodal neuroimaging, as well as cognitive and mental health data collected in adolescent twins over two sessions (session 1: N = 422, age 9-14 years; session 2: N = 304, 10-16 years). The MRI protocol consisted of T1-weighted (MP2RAGE), T2-weighted, FLAIR, high-resolution TSE, SWI, resting-state fMRI, DWI, and ASL scans. Two fMRI tasks were added in session 2 to probe emotion-relevant neural processes (emotional conflict task) and evoke activity in the Theory of Mind network (passive movie watching task). Outside of the scanner, we assessed cognitive function using standardised tests, obtained self-reports of symptoms for anxiety and depression, perceived stress, sleepiness, as well as measures of pubertal development, peer relationships, early life factors, and family sociodemographic factors. We additionally collected several biological samples for genomic and metagenomic analysis. The QTAB project was established with the purpose of promoting the conduct of health-related research in adolescence. Note: Basic demographic data (age [rounded down], sex, handedness) is provided at the top-level of the dataset directory in participants.tsv. Restricted demographic data (i.e., age in months, zygosity, zygosity source, multiple birth status, birth order), as well as non-imaging phenotypic data is is available through the Zenodo data sharing platform as a restricted access dataset (https://doi.org/10.5281/zenodo.7353053). Users can request access to the dataset through the Zenodo platform. Applicants are required to complete and abide by a data usage agreement.
昆士兰双胞胎青少年脑科学（Queensland Twin Adolescent Brain, QTAB）项目 本文详述昆士兰双胞胎青少年脑科学数据集的相关信息，并提供详尽的方法学与技术验证方案，以助力该数据集的规范使用。QTAB数据集包含多模态神经影像学数据，以及针对青少年双胞胎在两次扫描中收集的认知与心理健康数据：第一次扫描样本量为422例，受试年龄范围9~14岁；第二次扫描样本量为304例，受试年龄范围10~16岁。 本次MRI扫描方案涵盖T1加权成像（T1-weighted, MP2RAGE）、T2加权成像、FLAIR序列、高分辨率TSE序列、SWI序列、静息态功能磁共振成像（resting-state fMRI）、扩散加权成像（DWI）以及动脉自旋标记（ASL）扫描。第二次扫描新增两项fMRI任务：其一为情绪冲突任务，用于探究与情绪相关的神经加工过程；其二为被动电影观看任务，用于激活心理理论（Theory of Mind）网络。 在磁共振扫描仪外，研究团队采用标准化测试评估受试的认知功能，收集了焦虑、抑郁症状、感知压力、嗜睡程度的自评报告，同时采集了青春期发育状况、同伴关系、早期生活经历以及家庭社会人口学特征相关的测量数据。此外，研究团队还收集了多份生物样本，用于基因组与宏基因组学分析。本QTAB项目的设立初衷是推动青春期健康相关研究的开展。 注：数据集目录顶层的participants.tsv文件中提供了基础人口学数据（年龄[向下取整]、性别、利手性）。受限人口学数据（即月龄、双生子分型、分型依据、多胎出生状态、出生顺序）以及非影像学表型数据，需通过Zenodo数据共享平台以受限访问数据集的形式获取（https://doi.org/10.5281/zenodo.7353053）。用户可通过Zenodo平台申请数据集访问权限，申请者需完成并遵守数据使用协议。
