Bioequivalence (BE) studies are most often conducted as crossover trials, and therefore establishing their required sample size necessitates specification of the within-person variance. Given that thi
An optimal target proportion is derived balancing between the needs of clinician and statistician considering a general criterion and binary treatment outcome. A response-adaptive procedure based on t
Supplemental material, sj-R-1-smm-10.1177_09622802221114544 for The benefits of covariate adjustment for adaptive multi-arm designs by Kim May Lee, David S. Robertson, Thomas Jaki and Richard Emsley i
Adaptive two-stage design with treatment selection, also called seamless Phase II/III design, has been recognized to save sample size and time to enhance the development of effective treatments. These
Covariate-adjusted response-adaptive (CARA) designs have gained widespread adoption for their clear benefits in enhancing experimental efficiency and participant welfare. These designs dynamically adj
