High non-protective, long-lasting antibody levels in malaria are associated with haplotype shifting in MHC-peptide-TCR complex formation: a new mechanism for immune evasion.

Indirect immunofluorescence (IFA) antibody titers were determined by testing the reactivity of immune monkey sera against synchronized late-stage schizonts from a continuous P. falciparum culture. One of 4 animals reacted by day 20 to this HABP analogue. Cysteine-glycine (CG) was added to the N- and C-termini of each peptide during synthesis to allow polymerization following oxidation.