Chidamide suppresses adipogenic differentiation of bone marrow derived mesenchymal stem cells. Chidamide suppresses adipogenic differentiation of bone marrow derived mesenchymal stem cells

To explore the potential mechanism of chidamide in BM-MSC-mediated adipogenesis, we have employed mRNA microarray expression profiling platform to identify significant differential genes associated with adipogenic differentiation and chidamide management. Overall design: BM-MSCs were untreated (UN) or induced towards adipogenic differentiation (AD) simultaneously added with DMSO (DMSO) or chidamide (CHI) for 8 days. Then the four groups of cells were collected and mRNA microarray was performed.