Total Synthesis of (±)-Nardoaristolone B and Its Analogues

The first total synthesis
of nardoaristolone B, a nor-sesquiterpenoid
with an unusual fused ring system and having protective effects on
the injury of neonatal rat cardiomyocytes, has been accomplished.
Stereoselective synthesis of its novel analogues inlcuding exo-cyclopropyl ring fusion is also part of this disclosure.
In addition, an alternate and more efficient one-step method to make
a 3/5/6 tricyclic ring system using the Robinson annulation method
has been developed toward the generation of a library of compounds
around this skeleton.