Number of volunteers experiencing unsolicited adverse events during 28 days following each immunization.

Unsolicited adverse events were recorded on days 0, 1, 2, 7, 14 and 28 after each immunization. Severity classification: (a) bruising at the injection site: Gr1 = <5 cm in diameter; (b) all other signs and symptoms: Gr1 = adverse event does not interfere with daily activities; Gr2 = interferes with but does not prevent daily activities; Gr3 = prevents daily activities. All local adverse events occurred in the arm ipsilateral to the injection site. In addition to the AEs recorded in this table, there was one SAE recorded after the 3rd DNA immunization – see text.
*The same volunteer experienced radicular pain immediately post jet injection for DNA1 and DNA2 but not DNA3.