Shift from androgen to estrogen action causes fibrosis, abdominal muscle atrophy, and inguinal herniation in males. Mus musculus

Local biosynthesis of estrogen in lower abdominal skeletal muscle tissue leads to estrogen receptor-α-mediated fibrosis, muscle atrophy, and inguinal hernia. We used microarrays to detail the gene expression after aromatase expression in lower abdominal muscle tissue and identify distinct classes of up-regulated or down-regulated genes. Overall design: Total RNA obtained from lower abdominal muscle tissues of humanized aromatase transgneic mice (AromhumL and AromhumH) compared to those of wild type (WT) mice.