The effect of ANGPTL3 mAb on liver transcriptomes in LDLR-deficient mice. The effect of ANGPTL3 mAb on liver transcriptomes in LDLR-deficient mice

Purpose: The goal of this study was to evaluate the effect of ANGPTL3 inhibition on liver transcriptomes in LDLR KO mice. Methods: Mice were treated once weekly for 3 weeks with 25mg/kg control mAb or ANGPTL3 mAb. Livers were harvested 6 days after the last mAb treatment. Results: ANGPTL3 inhibition had no major impact on hepatic gene expression. Overall design: Liver mRNA profiles of ~16 weeks old LDLR KO mice were generated by deep sequencing using Illumina HiSeq2000.