Lithium-induced NDI is attenuated in PKCα KO mice.

WT and PKCα KO mice were provided standard chow or chow containing lithium (40 mmol/kg) for 6 weeks. Single animals were subsequently placed in individual metabolic cages to determine 24-h water intake. Urine and serum were also collected at this time point for metabolic determinations. Uprot/Uosm  =  urinary protein/urine osmolality ratio, CrCl/BW  =  creatinine clearance normalized to body weight (29–30 g). Data are presented as mean ± SEM where *  =  p<0.05 vs. WT day 0 and §  =  p<0.05 vs. PKCα KO day 0 is deemed significantly different. n = 5.