TrackRAD2025 Grand Challenge Dataset: Real-time Tumor Tracking for MRI-guided Radiotherapy

Accessing the data 🗃️Overall, TrackRAD2025 will have over 2.5 million unlabelled sagittal cine-MRI frames from 500 individual patients, and over 10,000 labelled sagittal cine-MRI frames (+8000 from frames with multiple observers) from 110 individual patients. Precisely, a cohort of 500 unlabeled and 110 manually labeled patients has been prepared for participants. For each patient, 2D sagittal cine MRI data (time-resolved sequence of 2D images) has been acquired during the course of radiotherapy treatments at 0.35 T (ViewRay MRIdian) or 1.5 T (Elekta Unity) MRI-linacs from six international centers. Tracking targets (typically tumors) in the thorax, abdomen and pelvis were included as these can be affected by motion and reflect the most often treated anatomies on MRI-linacs. The training set, which comprises the 500 unlabeled cases plus 50 labeled cases was publicly released. Participants can further subdivide this dataset locally into training and validation. The remaining 60 labeled cases building the preliminary and final testing set is only accessible for evaluation via submission to the challenge. Detailed information about the dataset are provided in "link data paper (expected early 2025)". Data locationThe training (and validation) dataset can be downloaded from this page. The preliminary testing and final testing dataset are not provided to participants, but are accessible by uploading algorithms for evaluation (https://trackrad2025.grand-challenge.org/). Data structureEach patient's data, both for the training and for the testing dataset, is organized using the following folder structure: dataset/|-- <patient>/| |-- field-strength.json| |-- frame-rate.json| |-- scanned-region.json| |-- images/| | |-- <patient_id>_frames.mha| | `-- <patient_id>_frames<scan>.mha -> additional scans (for some of the unlabeled cases)| `-- targets/| |-- <patient_id>_first_label.mha | |-- <patient_id>_labels.mha| `-- <patient_id>_labels<observer>.mha -> additional observers (for some of the labeled cases)|-- D_001/ -> this is a labeled case| |-- field-strength.json -> 0.35| |-- frame-rate.json -> 4.0| |-- scanned-region.json -> "thorax"| |-- images/| | `-- D_001_frames.mha| `-- targets/| |-- D_001_first_label.mha | `-- D_001_labels.mha|-- F_002/ -> this is an unlabeled case| |-- field-strength.json -> 1.5| |-- frame-rate.json -> 1.65| |-- scanned-region.json -> "abdomen"| `-- images/| |-- D_001_frames.mha| |-- D_001_frames2.mha -> second scan| `-- D_001_frames3.mha -> third scan from the same patient|-- F_003/`-- .../Please note that the dataset folder structure does not match the interfaces that submissions need to implement one-to-one. For details regarding submission requirements, please read the corresponding page. Data descriptionThis challenge provides 2D+t sagittal cine MRI data collected at six international centers: Amsterdam University Medical Center, Amsterdam Catharina Hospital, Eindhoven GenesisCare, Sydney LMU University Hospital, Munich Sichuan Cancer Center, Chengdu University Medical Center Utrecht, Utrecht For anonymization purposes, the provenance of the data is not provided, and each center is indicated with letters from A to F. One of the centers also provided cine data with an updated MRI sequence for gating at a 1.5 T MRI-linac, this data is indicated with the letter X. Training set 0.35 T MRI-linac A E Total Unlabeled 219 34 253 Labeled 25 - 25 1.5 T MRI-linac B C F Total Unlabeled 63 60 110? 233? Labeled 15 10 - 25 For training, centers A, B and C provided both unlabeled and manually labeled data while centers E and F provided solely unlabeled data. Preliminary testing set 0.35 T MRI-linac A Total Labeled 2 2 1.5 T MRI-linac B C Total Labeled 3 3 6 Final testing set 0.35 T MRI-linac A D Total Labeled 5 20 25 1.5 T MRI-linac B C X Total Labeled 8 11 6 25 For preliminary testing and final testing centers A, B, C, D and X provided manually labeled data. Data protocolsUnlabelled data protocol: For the unlabeled data in the training set, cine MRI from one or multiple radiotherapy MRI-linac treatment fractions were included. Cine MRI acquired during treatment for the 0.35 T MRI-linac also include frames with degraded image quality due to gantry rotations, which participants are free to exclude using a method of their choice. All frames from the 1.5 T MRI-linac were acquired during treatments only and do not present degradation due to gantry rotations due to machine design. In this set some patients present temporal jumps in the cine MRI due to paused treatment. Labelled data protocol: To avoid degraded images during evaluation, labeled frames for the 0.35 T MRI-linac were either chosen from simulation cine MRIs prior to treatment start or, when taken from treatments, a manual selection was performed to avoid periods of gantry rotation. All frames from the 1.5 T MRI-linac were acquired during treatments only and do not present degradation due to gantry rotations due to machine design. Human observers have generated the refer ence labels both for the training and testing sets. For dataset A, two observers (a medical student and a dentistry student) labeled the cine MRI frames using an in-house labeling tool developed for the challenge. For dataset B, a medical physics researcher (assistant professor) with more than 10 years experience in radiotherapy used the in-house labeling tool to delineate the frames. For dataset C, two radiation oncologists independently labeled the cine MRI frames using itk-snap. For dataset D, 4 radiation oncologists and one medical physicist have independently labeled the cine MRI frames using software provided by the 0.35 T MRI-linac vendor. For all labeled data, a medical physics doctoral student with 4 years experience in tumor tracking then reviewed and if necessary corrected all labels used in this challenge using the in-house tool. Data acquisition and pre-processingAll images were acquired using the clinically adopted imaging protocols of the respective centers for each anatomical site and reflect typical images found in daily clinical routine. The cine-MRI sequences used at the 0.35 T and 1.5 T MRI-linacs are standardized, which ensures uniformity of the data for a given field strength. At the centers using the 0.35 T MRI-linac, the 2D cine-MRIs were acquired in sagittal orientation with the patient in treatment position in the MRI-linac bore. During treatment simulation or delivery, the patients performed breath holds to increase the duty cycle of the gated radiation delivery. The breath-holds are followed by periods of regular breathing. The sequence was a 2D-balanced steady-state free precession (bSSFP) at 4 Hz or 8 Hz with a slice thickness of 5, 7 or 10 mm and pixel spacing of 2.4x2.4 or 3.5x3.5 mm2. At the centers using the 1.5 T MRI-linac, the 2D cine-MRIs were acquired in interleaved sagittal and coronal orientation with the patient in treatment position in the MRI-linac. For the challenge, only the sagittal plane has been considered. During treatment simulation or delivery, some patients performed breath holds to increase the duty cycle of the gated radiation delivery, while others breathed freely. The breath-holds are followed by periods of regular breathing. The sequence was a balanced fast field echo (bFFE) sequence at 1 Hz to 5 Hz with a slice thickness of 5, 7 or 8 mm and pixel spacing of 1.0x1.0 to 1.7x1.7 mm2. The following pre-processing steps were performed on the data: Conversion from proprietary formats to .mha Anonymization Reshaping and orientation correction Resampling to 1x1 mm2 in-plane pixel spacing Ethics Approvals The LMU University Hospital Munich ethics committee approved a corresponding clinical study entitled `Retrospective study on AI-based target tracking in magnetic resonance imaging-guided radiotherapy` on 23/01/2024 (study number 23-1043). UMC Utrecht approved a non-WMO request on 12/08/2024 with number 24U-1509 entitled: `TrackRad – tracking tumors for real time MRI-guided radiotherapy`. Contact persons: Department of Radiotherapy, University Medical Center Utrecht, [e-mail]; [e-mail]. Informed consent was obtained from all patients, and this study has been exempted by the VU University Medical Center Medical Ethics Review Committee (#2018.602, IRB00002991). The Sichuan Cancer Hospital ethics committee approved a corresponding clinical study entitled 'AI assisted precise MR-guided radiotherapy' on 29.04.2024 (study number: SCCHEC-02-2024-076). GenesisCare Research Governance granted approval on 16/12/2024 for a data access request with Project Title: "TrackRad Grand Challenge – tracking tumours for real-time MRI-guided radiotherapy" under the GenesisCare Oncology Outcomes protocol version 5 approved by St Vincent’s Sydney HREC. Patient data at the Catharina Hospital Eindhoven were retrospectively collected and fully anonymised. Therefore the requirement to obtain informed consent does not apply according to the Dutch Medical Research Involving Human Subjects Act.