Synthesis of the C1–C18 Fragment of Rhizopodin: Late-State Introduction of the Oxazole
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https://figshare.com/articles/dataset/Synthesis_of_the_C1_C18_Fragment_of_Rhizopodin_Late_State_Introduction_of_the_Oxazole/2317135
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The synthesis of the C1–C18 fragment of the myxobacteria metabolite rhizopodin is described. Initial attempts at installing the E,E-diene via cross coupling with an oxazole fragment gave poor results. An alternative approach, in which the diene was formed prior and the oxazole introduced by an acylation/O,N-shift protocol, gave the C1–C18 fragment 2 of rhizopodin (1).
创建时间:
2016-02-18



