Functional connection between zfp-1, rde-4 and insulin/PI3K signaling.

(A-C) Life span of indicated mutant strains (see Materials and Methods). (A) Mean life spans were significantly different between wild type and all mutants (Page-1, Pdaf-16, Pzfp-1, Pzfp-1; age-1). Data shown is from one representative experiment that has been performed three times. (B) Mean life spans were significantly different between wild type and both pdk-1 and zfp-1 mutants (Ppdk-1, Pzfp-1) while zfp-1 was found to be significantly different from zfp-1; pdk-1 (Ppdk-1, Prde-4, Prde-4; pdk-1). Data shown is from one representative experiment that has been performed two times. (D) Survival of L4 larva (n = 120) from indicated strains after 20 hour incubation period in 100mM paraquat: *** indicates significance of P# indicates significance of P## - P