Harmine and Exendin-4 Combination Therapy Safely Expands Human Beta Cell Mass In Vivo

NIAID Data Ecosystem2026-05-01 收录

糖尿病β细胞再生

药物组合疗法评估

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1035045 数据链接链接失效反馈

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Human islets were transplanted in Rag1-/- mice and treated with the drugs described below for 7 days.

创建时间：

2023-11-02

RNA-seq analysis in residual pancreatic Ã-cells of Bmal1KO/DTA mice following massive ablation

糖尿病β细胞再生

昼夜节律调控

We aimed to fill the gap in understanding functional roles of the islet cellular oscillators under diabetic conditions following massive Ã-cell ablation, and during Ã-cell regeneration. We assessed

NIAID Data Ecosystem50

Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β‑Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor

糖尿病β细胞再生

DYRK1A抑制剂

Recently, our group identified that harmine is able to induce β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT pathway. Since, harmine suffers from a lack of selectivity, b

NIAID Data Ecosystem30

Harmine and Exendin-4 Combination Therapy Safely Expands Human Beta Cell Mass In Vivo

糖尿病β细胞再生

药物联合疗法机制

537 million people globally suffer from diabetes. Insulin-producing beta cells are reduced in number in most people with diabetes, but the majority still have some residual beta cells. Disappointingly

NIAID Data Ecosystem20

Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation

糖尿病β细胞再生

小鼠遗传学模型

Beta-cell apoptosis and failure to induce beta-cell regeneration are hallmarks of type 2-like diabetes in mouse models. Here we show that islets from obese, diabetes-susceptible New Zealand Obese (NZO

Figshare2016-01-15 更新30

A noninterventional study evaluating the effectiveness of rotigotine and levodopa combination therapy in younger versus older patients with Parkinson’s disease

帕金森病药物

药物组合疗法评估

Background: PD0013 was a 6-month noninterventional study in clinical practice comparing effectiveness/tolerability of rotigotine+levodopa in younger ( Methods: Patients previously received levodopa fo

Figshare2018-07-11 更新20

Harmine and Exendin-4 Combination Therapy Safely Expands Human Beta Cell Mass In Vivo

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