Canonical pathways affected by differentially expressed miRNA-mRNA pairs.

The 480 differentially expressed genes targeted by miRNAs between SLKK and SLK cells were used as input for the Ingenuity pathway analysis (IPA). Here, we highlighted 4 of the top 10 enriched pathways that are relevant to KSHV pathogenesis. Columns identify the pathway name, its associated P-value, the ratio between dysregulated genes and genes in the pathway, which dysregulated target gene and miRNA are involved. Genes or miRNAs in bold and normal font were found up-regulated and down-regulated, respectively, by chronic KSHV infection.Canonical pathways affected by differentially expressed miRNA-mRNA pairs.