Age-adjusted RTL and anticipation in age at cancer diagnosis in parent-child pairs.

MMR: DNA mismatch repair; RTL: relative telomere length; CRC: colorectal cancer; EC: endometrial cancer; UC: urinary tract cancer; M: male; F: female; in surv: cancer diagnosed as a consequence of extensive clinical surveillance of LS families.*Age: Age at cancer diagnosis for cancer-afected carriers, and age at blood draw for cancer-free carriers and non-carriers**Telchildparent, age-adjusted telomere length is shorter in the child than in the parent. “Yes” indicates that age-adjusted RTL is smaller in the child than in the parent, therefore indicating association with anticipation when cancer-affected carriers are studied.***Cancer-free non-carriers are individuals who belong to Lynch syndrome families but do not carry the pathogenic MMR gene mutation.