Human conjunctival fibroblasts-LC-MS/MS

The underlying mechanisms of conjunctival fibrosis are complex and involve multiple factors and signaling pathway. Wnt/β-catenin signaling pathway plays an important role in organelle fibrosis. In this study, ICG-001 that inhibiting Wnt/β-catenin pathway has been applied in TGFβ1-induced fibrosis model of primary human conjunctival fibroblasts (HConFs). To verify the regulator of TGFβ1-induced conjunctival fibrosis, 4D DIA technology and proteomics analysis were used to identify the differentially expressed genes and the enrichment KEGG pathways.