Source Data Figure 6 .xlsx

<b>c</b>, Quantification of mRNA levels for <i>Sod3 </i>in articular cartilage tissue of rat OA model after vehicle or BNTA (1.5 mg kg^-1) treatment for 4 w (nonparametric test; n = 5 for each group), <i>SOD3</i> in human OA cartilage explants after vehicle or BNTA (0.1 μM) treatment for 3 w (unpaired two-tailed Student’s <i>t</i>-test; n = 5 for each group), and <i>Sod3</i> in interleukin 1 beta ( IL1β, 10 ng ml^-1)-induced rat OA chondrocytes after BNTA or vehicle treatment for 6 h (nonparametric test; n = 6 for each group). <b>d,</b> The extracellular and intracellular SOD activities in rat primary chondrocytes after treated with IL1β (10 ng ml^-1) or BNTA (0.1 μM) for 3 d (one-way ANOVA; n = 6 for each group).<b> e, </b>The ability to produce superoxide anions of culture media in IL1β (10 ng ml^-1)-induced rat OA chondrocytes incubated with BNTA (0.1 μM) for 2 d and 3 d, which was used to assess the extracellular superoxide anions content (one-way ANOVA; n = 6 for each group).<b> g, </b>Quantitative assay of superoxide anions in IL1β (10 ng ml^-1)-induced rat OA chondrocytes incubated with BNTA (0.1 μM) for 2 d, as assessed with MitoSOX Red staining (one-way ANOVA; n = 24 for each group). Scale bar, 25 μm. Data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01, ***<i>P</i> &lt; 0.001.