rat gut metagenome Genome sequencing

Naoxintong Capsule (NXT) is a formulated Traditional Chinese Medicine (TCM) widely applied in the treatment of cardiovascular and metabolomic diseases, most of which are closely related to hyperlipidemia as a major risk factor.NXT exerts potential preventive effect on hyperlipidemia. The body weight, serum lipid levels and liver function were all significantly alleviated. The gut microbiota of the HFD-fed rats were reconstituted with supplementation of NXT. The fecal levels of gut microbiota related metabolites, including BA and SCFA were also altered. The correlation between the gut microbiota and clinical/metabolomic parameters was then studied to reveal potential therapeutic biomarkers of NXT.