Kidney fibrosis, a scarring of the tubulo-interstitial space, is due to activation of interstitial myofibroblasts recruited locally or systemically with consecutive extracellular matrix deposition. Ne

NIAID Data Ecosystem40

Gene expression of LNCaP cells grown in 2D cultures and polyethlene glycol-based hydrogels with the presence of synthetic androgen, R1881. Homo sapiens

前列腺癌雄激素信号通路

细胞培养模型

Analysis of LNCaP cell molecular differences and their response to R1881 in 2D and 3D cultures. Androgen regulated genes were differentially expressed between 2D and 3D cultures. These results provide

NIAID Data Ecosystem30

Additional file 10 of Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer

乳腺癌药物机制

信号通路

Additional file 10. Ingenuity pathway analysis (IPA) indicating key molecular, cellular and signaling pathways likely impacted by Z-endoxifen treatment in the MCF7LR tumors.

Figshare2020-05-20 更新40

RNA-seq of MCF-7 cells treated with GDC-9545 and GNE-858

乳腺癌药物机制

RNA测序分析

We measured gene expression using RNA-sequencing for MCF-7 cells treated with vehicle (DMSO), GDC-9545 or GNE-858. GNE-858 is a non-ER degrader (SERM) from the same chemical series as GDC-9545. Overal

NIAID Data Ecosystem30

Pharmacological inhibition of 3D COL1-induced BIK expression in MCF-7 cells.

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