Time course of gene expression changes after muscle contraction in spinal cord injured rats

Purpose: The goal of this study was to determine the gene expression changes that occur over 7 days in parralyzed muscle in response to isometric contraction elicited by electrical stimulation initiated 4 months after spinal cord injury and to compare such changes to those observed in a normal muscle subjected to overload.本研究旨在明确：脊髓损伤（spinal cord injury）4个月后启动电刺激以诱发等长收缩（isometric contraction）时，瘫痪肌肉在7天周期内发生的基因表达变化，并将此类变化与承受超负荷（overload）的正常肌肉中观测到的基因表达变化进行对照比较。