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Total Synthesis and Target Identification of Marine Cyclopiane Diterpenes

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NIAID Data Ecosystem2026-05-02 收录
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We report our synthetic and chemical proteomics studies of marine cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target using an alkyne-tagged conidiogenone C-derived probe.

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2025-05-07
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