Crystal structure of MERS 3CL protease in complex with a m-fluorophenyl dimethyl sulfane inhibitor
收藏Protein Data Bank Japan2024-10-23 更新2026-04-25 收录
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Crystal structure of MERS 3CL protease in complex with a m-fluorophenyl dimethyl sulfane inhibitor Descriptor: Orf1a protein, [2-(3-fluorophenyl)sulfanyl-2-methyl-propyl] ~{N}-[(2~{S})-1-[[3-[(3~{S})-2-$l^{3}-oxidanylidenepyrrolidin-3-yl]-1-$l^{1}-oxidanylsulfonyl-1-oxidanyl-propan-2-yl]-$l^{2}-azanyl]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate Authors: Liu, L, Lovell, S, Battaile, K.P, Dampalla, C.S, Groutas, W.C. Deposit date: 2022-08-22 Release date: 2022-09-07 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV). Eur.J.Med.Chem., 254, 2023
创建时间：
2022-08-22
