Organocatalyzed Enantioselective Decarboxylative Stereoablation Reaction for the Construction of 3,3′-Disubstituted Oxindoles Using β‑Ketoacids and 3‑Halooxindoles
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https://figshare.com/articles/dataset/Organocatalyzed_Enantioselective_Decarboxylative_Stereoablation_Reaction_for_the_Construction_of_3_3_Disubstituted_Oxindoles_Using_Ketoacids_and_3_Halooxindoles/2457922
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资源简介：
An unprecedented method for the construction of optically
active
3,3′-disubstituted oxindoles via an organocatalyzed decarboxylative
stereoablation reaction has been developed. We describe the first
asymmetric reaction between β-ketoacids and 3-halooxindoles
utilizing an organocatalyst. This method allows for the formation
of a variety of 3,3′-disubstituted oxindoles bearing a keto-carbonyl
group, which are not easily accessible using other methodologies,
in moderate to good yields with high enantioselectivities.
创建时间：
2012-12-21
