Change in lentigo maligna score assessed by in vivo reflectance confocal microscopy after one month of imiquimod treatment for lentigo maligna management

Supplemental materials :

Figure 1 : Lentigo Maligna before Imiquimod treatment.
Confocal Microscopy mosaic images at the dermoepidermal junction. The mosaic shows signs of lentigo maligna with numerous bright atypical cells, even round, pagetoid (yellow arrowhead) and follicular localization of some atypical cells (blue arrowheads).

Figure 1A : Numerous bright hyperreflective atypical cells.

Figure 1B : Follicular localization of numerous atypical cells (yellow arrows). Non edged papillae with nucleated cells in the papilla.

Figure 2 : Lentigo maligna after 1 month of imiquimod treatment. Images of the mosaic reveal a restored honeycombed pattern with preserved follicular openings.

补充材料：
图1：使用伊莫iquimod治疗前的恶性雀斑样痣。
皮层-表皮交界处的共聚焦显微镜镶嵌图像。镶嵌图像显示出恶性雀斑样痣的迹象，其中包含众多明亮的非典型细胞，甚至包括圆形、Pagetoid（黄色箭头）以及某些非典型细胞的毛囊定位（蓝色箭头）。
图1A：众多明亮的超反射非典型细胞。
图1B：众多非典型细胞的毛囊定位（黄色箭头）。乳头边缘不明显，乳头内含有核细胞。
图2：经过一个月的伊莫iquimod治疗后恶性雀斑样痣。镶嵌图像显示恢复了蜂窝状图案，并保留了毛囊开口。